Publications

Books/Book Chapters

• Capillary electrophoresis of sulfated molecules. M Dantuluri and UR Desai (2003) Recent Research Developments in Analytical Biochemistry 3, 169-186.
• Cardiovascular agents. UR Desai (2004) The Chemistry of Drugs for Nurse Anesthetists (Eds. Drs. Lemont B. Kier and Cynthia Schiek), AANA Publishing, Park Ridge, IL, pp. 165-199.
• Antithrombin activation and designing novel heparin mimics. UR Desai (2005) In Chemistry and Biology of Heparin and Heparan Sulfate (Eds. HG Garg, RJ Linhardt and CA Hales), Elsevier, NY, pp. 483-512.
• Anticoagulants. BL Henry and UR Desai (2010). In Burger’s Medicinal Chemistry, Drug Discovery and Development (Eds. D Rotella and DJ Abraham), 7th Edition, John Wiley and Sons, NY pg. 365-408.
• Advances in the analysis of heparins. JT King and UR Desai (2012). In Heparin: Properties, Uses and Side Effects (Ed. DE Piyathilake and R Liang), Nova Science Publishers, NY, pp. 109-132.
Recent Publications

• Interaction of thrombin with sucrose octasulfate. BJ Desai, R Boothello, AY Mehta, JN Scarsdale, HT Wright and UR Desai (2011) Biochemistry 50, 6973-6982.
• Rational design of potent, small, synthetic allosteric inhibitors of thrombin. PS Sidhu, A Liang, AY Mehta, MA Aziz, Q Zhou and UR Desai (2011) Journal of Medicinal Chemistry 54, 5522-5531.
• Designing non-saccharide, allosteric activators of antithrombin for accelerated inhibition of factor Xa. RA Al-Horani, A Liang and UR Desai (2011) Journal of Medicinal Chemistry 54, 6125-6138.
• Identification of the site of binding of sulfated, low molecular weight lignins on thrombin. MH Abdel Aziz, PD Mosier and UR Desai (2011) Biochemical and Biophysical Research Communications 413, 348-352.
• Linear polyalkylamines as fingerprinting agents in capillary electrophoresis of low molecular weight heparins and glycosaminoglycans. JT King and UR Desai (2011) Electrophoresis 32, 3070-3077.
• Serpin – glycosaminoglycan interactions. C Rein, UR Desai and FC Church (2011) Methods in Enzymology 501, 105-137.
• Sulfated, low molecular weight lignins inhibit a select group of heparin-binding serine proteases. BL Henry, JN Thakkar, A Liang and UR Desai (2012) Biochemical and Biophysical Research Communications 417, 382-386.
• Electronically rich N-substituted tetrahydroisoquinoline 3-carboxylic acid esters: Concise synthesis and conformational studies. RA Al-Horani and UR Desai (2012) Tetrahedron 68, 2027-2040.
• Discovery of novel sulfonated small molecules that inhibit vascular tube formation. K Raman, R Karuturi, VP Swarup, UR Desai and B Kuberan (2012) Bioorganic and Medicinal Chemistry Letters 22, 4467-4470.
• Potent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold. RA Al-Horani, AY Mehta and UR Desai (2012) European Journal of Medicinal Chemistry 54, 771-783.
• Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with arg173 of exosite II to induce inhibition. MH Abdel Aziz, PS Sidhu, A Liang, JY Kim, PD Mosier, Q Zhou, DH Farrell and UR Desai (2012) Journal of Medicinal Chemistry 55, 6888-6897.
• Dynamic affinity chromatography in the separation of sulfated lignins binding to thrombin. A Liang, JN Thakkar, M Hindle and UR Desai (2012) Journal of Chromatography B 908, 45-51.
• On the specificity of heparin/heparan sulfate binding to proteins. Anion-binding sites on antithrombin and thrombin are fundamentally different. PD Mosier, C Krishnasamy, GE Kellogg, UR Desai (2012) PLoS One 7, e48632.
• On scaffold hopping: Challenges in the discovery of sulfated small molecules as mimetics of glycosaminoglycans. PS Sidhu, PD Mosier, Q Zhou, UR Desai (2013) Bioorganic and Medicinal Chemistry Letters 23, 355-359.
• The compensatory G88R change is essential in restoring the normal functions of influenza A viral matrix protein 1 with disrupted nuclear localization signal. H Xie, Z Lin, P Mosier, UR Desai, Y Gao (2013) Journal of Virology 87, 345-353.
• Sulfated pentagalloylglucoside is a potent, allosteric, and selective inhibitor of factor XIa. RA Al-Horani, P Ponnusamy, AY Mehta, D Gailani and UR Desai (2013) Journal of Medicinal Chemistry 56, 867-878.
• Novel low molecular weight lignins as anti-emphysema agents: In vitro triple inhibitory activities against elastase, oxidation and inflammation. B Saluja, JN Thakkar, H Li, UR Desai and M Sakagami (2013) Pulmonary Pharmacology and Therapeutics 26, 296-304.
• Sulfation patterns determine cellular internalization of heparin-like polysaccharides. K Raman, C Mencio, UR Desai and B Kuberan (2013) Molecular Pharmaceutics 10, 1442-1449.
• Discovery of allosteric modulators of factor XIa by targeting hydrophobic domains adjacent to its heparin-binding site. R Karuturi, RA Al-Horani, SC Mehta, D Gailani and UR Desai (2013) Journal of Medicinal Chemistry 56, 2415-2438.