Education

• Ph.D., Immunology & Immunochemistry (University of Manchester in U.K., 1973)
• B.Sc., Pharmacy (University of Manchester in U.K., 1970)

Post-Graduate Training

• Postdoctoral Fellow - Biopharmaceutics and Pharmacokinetics (Ohio State University, 1977)
• Postdoctoral Fellow - Pharmaceutics (University of Aston, 1975)

Academic Appointments/Professional Experience

• January 1999-Present. Chairman, Department of Pharmaceutics, Virginia Commonwealth University
• November 1995-December 2001. Visiting Professor, School of Pharmacy, University of Bath, Bath, U.K.
• June 1992-Present. Professor, Department of Pharmaceutics, Virginia Commonwealth University
• June 1988-1992. Associate Professor, Department of Pharmaceutics and Affiliate Professor of Biomedical Engineering, Virginia Commonwealth University
• 1984-1988. Assistant Professor of Pharmaceutics and Pharmaceutical Technology, University of Kentucky
• 1975-1984. Lecturer in Biopharmaceutics and Pharmocokinetics, Division of Pharmaceutics and Pharmaceutical Chemistry, University of Aston

Professional and Scholarly Interests

• Optimal design and evaluation of aerosol drug delivery systems
• Physical, chemical and formulation factors, and the impact of the aerosol generation device
• Pulmonary biopharmaceutics

Research Interests

• Our research is concerned with the optimal design and evaluation of aerosol drug delivery systems designed to target drugs to and via the lung. Effects of physical, chemical and formulation factors are studied, as well as the impact of the aerosol generation device. These factors are all related to our ability to deliver drugs by inhalation and target them to specific lung regions. Aerosols are characterized and evaluated in terms of particle size, shape, physical form and drug release characteristics in vitro and in vivo. In related research the effects of chemical structure and formulation variables are studied on absorption kinetics and lung disposition. Our biological research utilizes isolated lung preparations, whole animal studies and computer-based models to determine mechanisms of absorption, metabolism and retention for macromolecular and small molecular weight drugs.

The publications search is performed on the National Library of Medicine's PubMed database. The search may be slow during high traffic hours, may return articles authored by another researcher with a similar name and may not always find all of a researcher's articles.

Publications

Books/Book Chapters

• Dalby RN, Byron PR, Peart J, Suman JD, Farr SJ and Young P, Editors: Proceedings of Respiratory Drug Delivery 2008, Book 1, ISBN # 1-933722-21-5, Book 2, ISBN # 1-933722-22-3, Book 3, ISBN # 1-933722-23-1, Davis Healthcare International, River Grove, IL: 2008. Also at www.rddonline.org.
• Dalby RN, Byron PR, Peart J and Suman JD, Editors, Proceedings of RDD Europe 2007, Davis Healthcare International Publishing, IL 2007. Volume I ISBN # 1-933722-07-X.
• Dalby RN, Byron PR, Peart J and Suman JD and Farr SJ, Editors, Proceedings of Respiratory Drug Delivery 2006, Davis Healthcare International Publishing, IL 2006. Volume I ISBN # 1-930114-95-8; Volume II ISBN # 1-930114-96-6; Volume III ISBN # 1-930114-97-4.
Patents

• Byron PR, Dalby RN, U.S. Patent. "Formulation for Delivery of Drugs by Metered Dose Inhalers (MDIs) with Reduced or No Chlorofluorocarbon Content” US Patent # 5,190,029
• Peart J, Byron PR, Lichtman AH and Martin BR, U.S. Patent. "Delta 9 Tetrahydrocannabinol (Detla 9 THC) solution metered dose inhaler" US Patent # 6,509,005
Recent Publications

• Byron PR: “QbD: What Type of In Vivo-In Vitro Correlations are Feasible?” Proceedings of Respiratory Drug Delivery 2008. Davis Healthcare International, River Grove, IL. Volume 1: pp 125-132, 2008.
• Longest PW, Hindle M, Das Choudhuri S and Byron PR: “Developing a Better Understanding of Spray System Design Using a Combination of CFD Modeling and Experiment”, Proceedings of Respiratory Drug Delivery 2008, Davis Healthcare International, River Grove, IL, Volume 1: 151-164, 2008.
• Longest PW, Hindle M, Das Choudhuri S and Byron PR: “Numerical Simulations of Capillary Aerosol Generation: CFD Model Development and Comparisons with Experimental Data”, Aerosol Sci. Tech., 41:10, 952-973, 2007.
• Pang Y, Sakagami M and Byron PR: “Insulin Self-association: Effects of Lung Disposition Kinetics in the Airways of the Isolated Perfused Rat Lung”, Pharmaceutical Research, 24(9): 1636-1644, 2007.